After weeks of seeing and interacting with the deceased Denny, Izzie finally realizes that he isn't there because he’s a ghost—he's there because she is sick.

While the medical drama unfolds, the controversial Denny Duquette "ghost" storyline reaches its peak.

The central conflict revolves around William Dunn, a death-row inmate who wants to die in the hospital so he can donate his organs to Jackson Prescott, a young boy in desperate need of a transplant.

Meredith finds herself empathizing with a murderer, much to Derek's horror. She sees a human being; Derek sees the "monster" who destroyed families.