Yamazaki — Akari

: She contributed to vital studies in Nature Neuroscience evaluating how liver-expressed (peripheral) apoE4 compromises synaptic plasticity and exacerbates brain amyloid pathology. ⚗️ Focus 2: Akari Yamazaki in Organic Chemistry

This technique was detailed in the established protocol paper featured in STAR Protocols , which allows researchers to execute high sequencing depth of mouse brain vascular cells to study brain diseases. The Role of ApoE4 and Cerebrovascular Function akari yamazaki

Yamazaki's chemical research frequently focuses on and related fused-ring systems. Azulene is known for its deep blue color and unusual dipole moment, making its derivatives highly sought after for advanced materials and pharmaceuticals. : She contributed to vital studies in Nature

A significant portion of her co-authored work focuses on the apolipoprotein E (APOE) gene—specifically the ε4 allele, which is the strongest genetic risk factor for Alzheimer's disease. Azulene is known for its deep blue color

She established highly specialized cell isolation procedures to secure glio-vascular cell-enriched single-cell suspensions.

One of Yamazaki’s most notable technical contributions to the scientific community is her work on profiling the transcriptomics of the blood-brain barrier.

: Her research published in journals like Arteriosclerosis, Thrombosis, and Vascular Biology has demonstrated that ApoE in Brain Pericytes regulates endothelial cell phenotype. This showed that ApoE4 impairs the basement membrane formation of capillaries, contributing to cognitive decline.