110353 May 2026

: A thorough assessment of the risk for opioid addiction, abuse, or misuse must be conducted prior to starting therapy.

: Antihistamine combined with an opioid agonist.

-receptor sites. It does not bind to or inactivate histamine itself but prevents it from causing allergic responses. 110353

: Allergy, cold, and cough remedy; antitussive.

: Because opioids can cause significant constipation, bowel function should be routinely monitored. Patients are often encouraged to increase fluid and fiber intake or use stimulant laxatives if treatment exceeds 2–3 days. Contraindications and Risks : A thorough assessment of the risk for

According to the Davis’s Drug Guide , healthcare providers must monitor several critical factors:

: Crushing, chewing, or snorting the extended-release product can lead to an uncontrolled delivery of codeine, which may result in a fatal overdose. It does not bind to or inactivate histamine

: It is classified as a Schedule III controlled substance due to the presence of codeine. Mechanism of Action